Select Publications

Venkatesh, A, Jain, A, Davies, H, Periera, L, Maki, JN, Gomes, E et al.. Hospital-derived antibody profiles of malaria patients in Southwest India. Malaria Journal. 2019;18 (1):138. doi: 10.1186/s12936-019-2771-5.

White, J, Rathod, PK. Indispensable malaria genes. Science. 2018;360 (6388):490-491. doi: 10.1126/science.aat5092.

Mohanty, AK, Nina, PB, Ballav, S, Vernekar, S, Parkar, S, D’souza, M et al.. Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection. Malaria Journal. 2018;17 (1):225. doi: 10.1186/s12936-018-2343-0.

Chery, L, Maki, JN, Mascarenhas, A, Walke, JT, Gawas, P, Almeida, A et al.. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malaria Journal. 2016;15 (1):569. doi: 10.1186/s12936-016-1619-5.

Mudeppa, DG, Kumar, S, Kokkonda, S, White, J, Rathod, PK. Topoisomerase II from Human Malaria Parasites: Expression, purification, and selective inhibition. Journal of Biological Chemistry. 2015;290 (33):20313-24. doi: 10.1074/jbc.M115.639039.

Phillips, MA, Lotharius, J, Marsh, K, White, J, Dayan, A, White, KL et al.. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science Translational Medicine. 2015;7 (296):296ra111. doi: 10.1126/scitranslmed.aaa6645.

Guler, JL, Freeman, DL, Ahyong, V, Patrapuvich, R, White, J, Gujjar, R et al.. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. PLoS Pathogens. 2013;9 (5):e1003375. doi: 10.1371/journal.ppat.1003375.

Ganesan, K, Ponmee, N, Jiang, L, Fowble, JW, White, J, Kamchonwongpaisan, S et al.. A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathogens. 2008;4 (11):e1000214. doi: 10.1371/journal.ppat.1000214.

Rathod, PK, McErlean, T, Lee, PC. Variations in frequencies of drug resistance in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the U.S.A. 1997;94 (17):9389-93. doi: 10.1073/pnas.94.17.9389.

All Lab Publications

Dash, R, Skillman, KM, Pereira, L, Mascarenhas, A, Dass, S, Walke, J et al.. Development of a Plasmodium vivax biobank for functional ex vivo assays. Malar J. 2023;22 (1):250. doi: 10.1186/s12936-023-04668-2. PubMed PMID:37653486 PubMed Central PMC10470152.

Dash, R, Skillman, KM, Pereira, L, Mascarenhas, A, Dass, S, Walke, J et al.. Development of a Plasmodium vivax biobank for functional ex vivo assays. bioRxiv. 2023; :. doi: 10.1101/2023.03.17.533128. PubMed PMID:36993272 PubMed Central PMC10055260.

Chaudhary, Z, Rathod, PK, Nehra, A, Sharma, P. A case report of temporomandibular joint tuberculosis in a neonate with eleven years follow-up. J Oral Biol Craniofac Res. 2023;13 (2):360-363. doi: 10.1016/j.jobcr.2023.03.004. PubMed PMID:36941901 PubMed Central PMC10024123.

Bhogaraju, S, Sriramula, V, Uppada, UK, Rathod, PK. Gossypiboma: An Unintentional Iatrogenic Error. J Maxillofac Oral Surg. 2022;21 (4):1155-1158. doi: 10.1007/s12663-021-01593-2. PubMed PMID:36896076 PubMed Central PMC9989098.

Russo, TA, Umland, TC, Deng, X, El Mazouni, F, Kokkonda, S, Olson, R et al.. Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc Natl Acad Sci U S A. 2022;119 (51):e2213116119. doi: 10.1073/pnas.2213116119. PubMed PMID:36512492 PubMed Central PMC9907071.

Chakrabarti, R, Chery-Karschney, L, White, J, Mascarenhas, A, Skillman, KM, Kanjee, U et al.. Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India. Am J Trop Med Hyg. 2022;107 (4_Suppl):107-117. doi: 10.4269/ajtmh.21-1344. PubMed PMID:36228910 PubMed Central PMC9662227.

Mascarenhas, A, Chakrabarti, R, Chery-Karschney, L, White, J, Skillman, KM, Kanjee, U et al.. International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India. Am J Trop Med Hyg. 2022;107 (4_Suppl):118-123. doi: 10.4269/ajtmh.22-0005. PubMed PMID:36228906 PubMed Central PMC9662211.

Tan, S, Mudeppa, DG, Kokkonda, S, White, J 3rd, Patrapuvich, R, Rathod, PK et al.. Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase. Antimicrob Agents Chemother. 2021;65 (9):e0058621. doi: 10.1128/AAC.00586-21. PubMed PMID:34152814 PubMed Central PMC8370227.

Venkatesh, A, Jain, A, Davies, H, Felgner, PL, Rathod, PK, Patankar, S et al.. Protein Arrays for the Identification of Seroreactive Protein Markers for Infectious Diseases. Methods Mol Biol. 2021;2344 :139-150. doi: 10.1007/978-1-0716-1562-1_10. PubMed PMID:34115357 .

Mohanty, AK, de Souza, C, Harjai, D, Ghavanalkar, P, Fernandes, M, Almeida, A et al.. Optimization of Plasmodium vivax sporozoite production from Anopheles stephensi in South West India. Malar J. 2021;20 (1):221. doi: 10.1186/s12936-021-03767-2. PubMed PMID:34006297 PubMed Central PMC8129701.

Palmer, MJ, Deng, X, Watts, S, Krilov, G, Gerasyuto, A, Kokkonda, S et al.. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J Med Chem. 2021;64 (9):6085-6136. doi: 10.1021/acs.jmedchem.1c00173. PubMed PMID:33876936 PubMed Central PMC8171248.

Clark, MA, Kanjee, U, Rangel, GW, Chery, L, Mascarenhas, A, Gomes, E et al.. Plasmodium vivax infection compromises reticulocyte stability. Nat Commun. 2021;12 (1):1629. doi: 10.1038/s41467-021-21886-x. PubMed PMID:33712609 PubMed Central PMC7955053.

Rathod, PK, Yadav, R, Bhutia, O, Roychoudhury, A, Bhatt, K, Kaur, K et al.. Is Zygomatic Osteotomy a Viable Option to Achieve Symmetry and Stability in Post-traumatic Residual Deformity of the Zygomaticomaxillary Complex?. J Oral Maxillofac Surg. 2021;79 (6):1328.e1-1328.e13. doi: 10.1016/j.joms.2021.01.017. PubMed PMID:33610490 .

McDaniels, JM, Huckaby, AC, Carter, SA, Lingeman, S, Francis, A, Congdon, M et al.. Extrachromosomal DNA amplicons in antimalarial-resistant Plasmodium falciparum. Mol Microbiol. 2021;115 (4):574-590. doi: 10.1111/mmi.14624. PubMed PMID:33053232 PubMed Central PMC8246734.

Kanjee, U, Grüring, C, Babar, P, Meyers, A, Dash, R, Pereira, L et al.. Plasmodium vivax Strains Use Alternative Pathways for Invasion. J Infect Dis. 2021;223 (10):1817-1821. doi: 10.1093/infdis/jiaa592. PubMed PMID:32941614 PubMed Central PMC8161644.

Kokkonda, S, Deng, X, White, KL, El Mazouni, F, White, J, Shackleford, DM et al.. Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. J Med Chem. 2020;63 (9):4929-4956. doi: 10.1021/acs.jmedchem.0c00311. PubMed PMID:32248693 PubMed Central PMC7394244.

Chakrabarti, R, White, J, Babar, PH, Kumar, S, Mudeppa, DG, Mascarenhas, A et al.. Decreased In Vitro Artemisinin Sensitivity of Plasmodium falciparum across India. Antimicrob Agents Chemother. 2019;63 (10):. doi: 10.1128/AAC.00101-19. PubMed PMID:31332065 PubMed Central PMC6761557.

Duffy, F, Bernabeu, M, Babar, PH, Kessler, A, Wang, CW, Vaz, M et al.. Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults. mBio. 2019;10 (2):. doi: 10.1128/mBio.00217-19. PubMed PMID:31040236 PubMed Central PMC6495371.

Venkatesh, A, Jain, A, Davies, H, Periera, L, Maki, JN, Gomes, E et al.. Hospital-derived antibody profiles of malaria patients in Southwest India. Malar J. 2019;18 (1):138. doi: 10.1186/s12936-019-2771-5. PubMed PMID:30995911 PubMed Central PMC6472095.

Narayan, A, Mastud, P, Thakur, V, Rathod, PK, Mohmmed, A, Patankar, S et al.. Heterologous expression in Toxoplasma gondii reveals a topogenic signal anchor in a Plasmodium apicoplast protein. FEBS Open Bio. 2018;8 (11):1746-1762. doi: 10.1002/2211-5463.12527. PubMed PMID:30410855 PubMed Central PMC6212639.

White, J, Dhingra, SK, Deng, X, El Mazouni, F, Lee, MCS, Afanador, GA et al.. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis. 2019;5 (1):90-101. doi: 10.1021/acsinfecdis.8b00211. PubMed PMID:30375858 PubMed Central PMC6467762.

Kaushansky, A, Hedstrom, L, Goldman, A, Singh, J, Yang, PL, Rathod, PK et al.. A call to arms: Unifying the fight against resistance. Sci Signal. 2018;11 (553):. doi: 10.1126/scisignal.aav0442. PubMed PMID:30352947 PubMed Central PMC6464114.

Kokkonda, S, El Mazouni, F, White, KL, White, J, Shackleford, DM, Lafuente-Monasterio, MJ et al.. Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity. ACS Omega. 2018;3 (8):9227-9240. doi: 10.1021/acsomega.8b01573. PubMed PMID:30197997 PubMed Central PMC6120730.

Mohanty, AK, Nina, PB, Ballav, S, Vernekar, S, Parkar, S, D'souza, M et al.. Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection. Malar J. 2018;17 (1):225. doi: 10.1186/s12936-018-2343-0. PubMed PMID:29871629 PubMed Central PMC5989471.

White, J, Rathod, PK. Indispensable malaria genes. Science. 2018;360 (6388):490-491. doi: 10.1126/science.aat5092. PubMed PMID:29724941 PubMed Central PMC6469853.

Rangel, GW, Clark, MA, Kanjee, U, Lim, C, Shaw-Saliba, K, Menezes, MJ et al.. Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays. Antimicrob Agents Chemother. 2018;62 (4):. doi: 10.1128/AAC.02519-17. PubMed PMID:29378713 PubMed Central PMC5913983.

Patankar, S, Sharma, S, Rathod, PK, Duraisingh, MT. Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax. Proteomics Clin Appl. 2018;12 (4):e1700024. doi: 10.1002/prca.201700024. PubMed PMID:29193853 PubMed Central PMC5975085.

Balabaskaran Nina, P, Mohanty, AK, Ballav, S, Vernekar, S, Bhinge, S, D'souza, M et al.. Dynamics of Plasmodium vivax sporogony in wild Anopheles stephensi in a malaria-endemic region of Western India. Malar J. 2017;16 (1):284. doi: 10.1186/s12936-017-1931-8. PubMed PMID:28693607 PubMed Central PMC5504555.

Chery, L, Maki, JN, Mascarenhas, A, Walke, JT, Gawas, P, Almeida, A et al.. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016;15 (1):569. doi: 10.1186/s12936-016-1619-5. PubMed PMID:27884146 PubMed Central PMC5123287.

Hostetler, JB, Lo, E, Kanjee, U, Amaratunga, C, Suon, S, Sreng, S et al.. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. PLoS Negl Trop Dis. 2016;10 (10):e0005091. doi: 10.1371/journal.pntd.0005091. PubMed PMID:27798646 PubMed Central PMC5087946.

Phillips, MA, White, KL, Kokkonda, S, Deng, X, White, J, El Mazouni, F et al.. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis. 2016;2 (12):945-957. doi: 10.1021/acsinfecdis.6b00144. PubMed PMID:27641613 PubMed Central PMC5148661.

Kumar, S, Mudeppa, DG, Sharma, A, Mascarenhas, A, Dash, R, Pereira, L et al.. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016;210 (1-2):1-4. doi: 10.1016/j.molbiopara.2016.07.005. PubMed PMID:27457272 PubMed Central PMC5249597.

Shaw-Saliba, K, Clarke, D, Santos, JM, Menezes, MJ, Lim, C, Mascarenhas, A et al.. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. Int J Parasitol. 2016;46 (11):679-83. doi: 10.1016/j.ijpara.2016.06.003. PubMed PMID:27456552 PubMed Central PMC5028309.

Lim, C, Pereira, L, Saliba, KS, Mascarenhas, A, Maki, JN, Chery, L et al.. Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates. J Infect Dis. 2016;214 (7):1081-4. doi: 10.1093/infdis/jiw303. PubMed PMID:27432121 PubMed Central PMC5021230.

Bernabeu, M, Danziger, SA, Avril, M, Vaz, M, Babar, PH, Brazier, AJ et al.. Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass. Proc Natl Acad Sci U S A. 2016;113 (23):E3270-9. doi: 10.1073/pnas.1524294113. PubMed PMID:27185931 PubMed Central PMC4988613.

Kokkonda, S, Deng, X, White, KL, Coteron, JM, Marco, M, de Las Heras, L et al.. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016;59 (11):5416-31. doi: 10.1021/acs.jmedchem.6b00275. PubMed PMID:27127993 PubMed Central PMC4904246.

Lim, C, Pereira, L, Shardul, P, Mascarenhas, A, Maki, J, Rixon, J et al.. Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia. Am J Hematol. 2016;91 (8):852-5. doi: 10.1002/ajh.24383. PubMed PMID:27074559 PubMed Central PMC5814318.

Panda, S, Nanda, R, Mangaraj, M, Rathod, PK, Mishra, PK. Glycemic Status in Organophosphorus Poisoning. J Nepal Health Res Counc. 2015;13 (31):214-9. . PubMed PMID:27005715 .

Kumar, A, Hosmani, R, Jadhav, S, de Sousa, T, Mohanty, A, Naik, M et al.. Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission. Malar J. 2016;15 :124. doi: 10.1186/s12936-016-1177-x. PubMed PMID:26919828 PubMed Central PMC4769513.

White, J 3rd, Mascarenhas, A, Pereira, L, Dash, R, Walke, JT, Gawas, P et al.. In vitro adaptation of Plasmodium falciparum reveal variations in cultivability. Malar J. 2016;15 :33. doi: 10.1186/s12936-015-1053-0. PubMed PMID:26794408 PubMed Central PMC4722725.

Mullowney, MW, Hwang, CH, Newsome, AG, Wei, X, Tanouye, U, Wan, B et al.. Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis. ACS Infect Dis. 2015;1 (4):168-174. doi: 10.1021/acsinfecdis.5b00005. PubMed PMID:26594660 PubMed Central PMC4648258.

Cui, L, Mharakurwa, S, Ndiaye, D, Rathod, PK, Rosenthal, PJ. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015;93 (3 Suppl):57-68. doi: 10.4269/ajtmh.15-0007. PubMed PMID:26259943 PubMed Central PMC4574275.

Wassmer, SC, Taylor, TE, Rathod, PK, Mishra, SK, Mohanty, S, Arevalo-Herrera, M et al.. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015;93 (3 Suppl):42-56. doi: 10.4269/ajtmh.14-0841. PubMed PMID:26259939 PubMed Central PMC4574273.

Phillips, MA, Lotharius, J, Marsh, K, White, J, Dayan, A, White, KL et al.. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015;7 (296):296ra111. doi: 10.1126/scitranslmed.aaa6645. PubMed PMID:26180101 PubMed Central PMC4539048.

Mudeppa, DG, Kumar, S, Kokkonda, S, White, J, Rathod, PK. Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION. J Biol Chem. 2015;290 (33):20313-24. doi: 10.1074/jbc.M115.639039. PubMed PMID:26055707 PubMed Central PMC4536438.

Kumar, S, Krishnamoorthy, K, Mudeppa, DG, Rathod, PK. Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallogr F Struct Biol Commun. 2015;71 (Pt 5):600-8. doi: 10.1107/S2053230X1500549X. PubMed PMID:25945715 PubMed Central PMC4427171.

Deng, X, Matthews, D, Rathod, PK, Phillips, MA. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Acta Crystallogr F Struct Biol Commun. 2015;71 (Pt 5):553-9. doi: 10.1107/S2053230X15000989. PubMed PMID:25945708 PubMed Central PMC4427164.

Guler, JL, White, J 3rd, Phillips, MA, Rathod, PK. Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor. Antimicrob Agents Chemother. 2015;59 (1):686-9. doi: 10.1128/AAC.02347-14. PubMed PMID:25331708 PubMed Central PMC4291421.

Deng, X, Kokkonda, S, El Mazouni, F, White, J, Burrows, JN, Kaminsky, W et al.. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem. 2014;57 (12):5381-94. doi: 10.1021/jm500481t. PubMed PMID:24801997 PubMed Central PMC4079327.

Mudeppa, DG, Rathod, PK. Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system. Eukaryot Cell. 2013;12 (12):1653-63. doi: 10.1128/EC.00222-13. PubMed PMID:24123271 PubMed Central PMC3889570.

Mailu, BM, Ramasamay, G, Mudeppa, DG, Li, L, Lindner, SE, Peterson, MJ et al.. A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway. J Biol Chem. 2013;288 (45):32539-32552. doi: 10.1074/jbc.M113.507467. PubMed PMID:24072705 PubMed Central PMC3820887.

Herricks, T, Avril, M, Janes, J, Smith, JD, Rathod, PK. Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions. Eukaryot Cell. 2013;12 (11):1490-8. doi: 10.1128/EC.00148-13. PubMed PMID:24014767 PubMed Central PMC3837943.

Guler, JL, Freeman, DL, Ahyong, V, Patrapuvich, R, White, J, Gujjar, R et al.. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. PLoS Pathog. 2013;9 (5):e1003375. doi: 10.1371/journal.ppat.1003375. PubMed PMID:23717205 PubMed Central PMC3662640.

Herricks, T, Seydel, KB, Molyneux, M, Taylor, T, Rathod, PK. Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients. Cell Microbiol. 2012;14 (12):1880-91. doi: 10.1111/cmi.12007. PubMed PMID:22892025 PubMed Central PMC3501548.

Marwaha, A, White, J, El Mazouni, F, Creason, SA, Kokkonda, S, Buckner, FS et al.. Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem. 2012;55 (17):7425-36. doi: 10.1021/jm300351w. PubMed PMID:22877245 PubMed Central PMC3446820.

Narayanasamy, K, Chery, L, Basu, A, Duraisingh, MT, Escalante, A, Fowble, J et al.. Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012;121 (3):256-66. doi: 10.1016/j.actatropica.2012.01.008. PubMed PMID:22266213 PubMed Central PMC3894252.

Kumar, A, Chery, L, Biswas, C, Dubhashi, N, Dutta, P, Dua, VK et al.. Malaria in South Asia: prevalence and control. Acta Trop. 2012;121 (3):246-55. doi: 10.1016/j.actatropica.2012.01.004. PubMed PMID:22248528 PubMed Central PMC3808995.

Herricks, T, Seydel, KB, Turner, G, Molyneux, M, Heyderman, R, Taylor, T et al.. A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells. Lab Chip. 2011;11 (17):2994-3000. doi: 10.1039/c1lc20131j. PubMed PMID:21743938 PubMed Central PMC3809019.

Coteron, JM, Marco, M, Esquivias, J, Deng, X, White, KL, White, J et al.. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011;54 (15):5540-61. doi: 10.1021/jm200592f. PubMed PMID:21696174 PubMed Central PMC3156099.

Gujjar, R, El Mazouni, F, White, KL, White, J, Creason, S, Shackleford, DM et al.. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem. 2011;54 (11):3935-49. doi: 10.1021/jm200265b. PubMed PMID:21517059 PubMed Central PMC3124361.

Kumar, A, Dua, VK, Rathod, PK. Malaria-attributed death rates in India. Lancet. 2011;377 (9770):991-2; author reply 994-5. doi: 10.1016/S0140-6736(11)60379-6. PubMed PMID:21420546 PubMed Central PMC3883669.

Ganesan, SM, Morrisey, JM, Ke, H, Painter, HJ, Laroiya, K, Phillips, MA et al.. Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Mol Biochem Parasitol. 2011;177 (1):29-34. doi: 10.1016/j.molbiopara.2011.01.004. PubMed PMID:21251930 PubMed Central PMC3057331.

Guiguemde, WA, Shelat, AA, Bouck, D, Duffy, S, Crowther, GJ, Davis, PH et al.. Chemical genetics of Plasmodium falciparum. Nature. 2010;465 (7296):311-5. doi: 10.1038/nature09099. PubMed PMID:20485428 PubMed Central PMC2874979.

Phillips, MA, Rathod, PK. Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets. 2010;10 (3):226-39. doi: 10.2174/187152610791163336. PubMed PMID:20334617 PubMed Central PMC2883174.

Sun, XE, Sharling, L, Muthalagi, M, Mudeppa, DG, Pankiewicz, KW, Felczak, K et al.. Prodrug activation by Cryptosporidium thymidine kinase. J Biol Chem. 2010;285 (21):15916-22. doi: 10.1074/jbc.M110.101543. PubMed PMID:20231284 PubMed Central PMC2871459.

Larson, ET, Mudeppa, DG, Gillespie, JR, Mueller, N, Napuli, AJ, Arif, JA et al.. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol. 2010;396 (5):1244-59. doi: 10.1016/j.jmb.2010.01.013. PubMed PMID:20070944 PubMed Central PMC2844865.

Deng, X, Gujjar, R, El Mazouni, F, Kaminsky, W, Malmquist, NA, Goldsmith, EJ et al.. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009;284 (39):26999-7009. doi: 10.1074/jbc.M109.028589. PubMed PMID:19640844 PubMed Central PMC2785385.

Pang, CK, Hunter, JH, Gujjar, R, Podutoori, R, Bowman, J, Mudeppa, DG et al.. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Mol Biochem Parasitol. 2009;168 (1):74-83. doi: 10.1016/j.molbiopara.2009.06.011. PubMed PMID:19591883 PubMed Central PMC2741015.

Herricks, T, Antia, M, Rathod, PK. Deformability limits of Plasmodium falciparum-infected red blood cells. Cell Microbiol. 2009;11 (9):1340-53. doi: 10.1111/j.1462-5822.2009.01334.x. PubMed PMID:19438513 PubMed Central PMC2774476.

Gujjar, R, Marwaha, A, El Mazouni, F, White, J, White, KL, Creason, S et al.. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem. 2009;52 (7):1864-72. doi: 10.1021/jm801343r. PubMed PMID:19296651 PubMed Central PMC2746568.

Ganesan, K, Ponmee, N, Jiang, L, Fowble, JW, White, J, Kamchonwongpaisan, S et al.. A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathog. 2008;4 (11):e1000214. doi: 10.1371/journal.ppat.1000214. PubMed PMID:19023412 PubMed Central PMC2581438.

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